"chaozbandit" (chaozbandit)
10/28/2020 at 10:37 • Filed to: folding@home
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"chaozbandit" (chaozbandit)
10/28/2020 at 10:37 • Filed to: folding@home | 17
| 12 |
In its SARS-CoV-2 simulations, F@h first targeted the spike, the cone-shaped appendages on the surface of the virus consisting of three proteins. The spike must open to attach itself to a human cell to infiltrate and replicate. F@h’s mission was to simulate this opening process to gain unique insight into what the open state looks like and find a way to inhibit the connection between the spike and human cells.
...
Dr. Greg Bowman, associate professor of biochemistry at Washington University and leader of Folding@home, said the spikes hide from the immune system by folding up on themselves to protect their receptor-binding sites, kind of like how a turtle pulls into its shell. Eventually, though, they would have to open up to find a potential host.
...
The model derived from the F@h simulations shows that the spike opens up and exposes buried surfaces. These surfaces are necessary for infecting a human cell and can also be targeted with antibodies or antivirals that bind to the surface to neutralize the virus and prevent it from infecting someone.
“By generating over 100-fold more data than anyone else has access to, we were able to capture events like a dramatic opening of the spike that exposes surfaces one wouldn’t otherwise have expected were viable targets. Likewise, we also found opening motions that create novel pockets in many other viral proteins. All these new structural features could be useful drug targets. We’re sharing all the data online so that others can use it to understand the virus and develop antivirals in parallel with our own efforts,” Bowman said.
Read the full article here:
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Please continue to contribute resources (FAH or BOINC) if you can. Stay s afe everyone.
barnie
> chaozbandit
10/28/2020 at 11:01 |
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We must be reading the same news sites. Just posted about this, too. Glad and grateful we are helping.
BaconSandwich is tasty.
> chaozbandit
10/28/2020 at 11:06 |
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I was slightly worried I smelled something slightly amiss with my computer this morning, and was thinking I might have to scale things back a bit. :(
I’ve been running Folding@Home day and night for the last few months. I’ve got to have my computer on during the work day anyway, so I might as well put it to use. I wish I had a more powerful GPU so I could help more.
HammerheadFistpunch
> chaozbandit
10/28/2020 at 11:10 |
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I freaking love the scientific community.
“we put a shit ton of time and money into a unique tool that no one else has...you guys want the results? No charge”
Grindintosecond
> chaozbandit
10/28/2020 at 11:19 |
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For the lucky few who have a RTX-3000 card, I’ve seen mention lately of people getting 3.9-4.1m ppd on a 3080 founders edition card.
A nice 3070 for $500 would be a great solution to any desktop system. A nice long term investment in all this.
dogisbadob
> chaozbandit
10/28/2020 at 11:19 |
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Wow that is cool
Chariotoflove
> HammerheadFistpunch
10/28/2020 at 11:21 |
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Oh, we paid for it. And the grants require as a condition of the contract that the data be shared if done with public funds.
Still amazingly cool way to live. We don’t do it for the money. We do it to make a difference like this.
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HammerheadFistpunch
> Chariotoflove
10/28/2020 at 11:26 |
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yeah, thats definitely the whole story, but the net effect is the same.
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chaozbandit
> Grindintosecond
10/28/2020 at 11:48 |
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This is correct, though the big ampere cards are still very much under utilized with the current crop of projects.
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BaconSandwich is tasty.
> chaozbandit
10/28/2020 at 12:15 |
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That’s crazy.
Where’d you capture this from?
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chaozbandit
> BaconSandwich is tasty.
10/28/2020 at 12:21 |
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https://folding.lar.systems/folding_data/gpu_ppd_overall
LAR systems has arguably the
most up to date FAH
gpu database imo
.
Rusty Vandura - www.tinyurl.com/keepoppo
> chaozbandit
10/28/2020 at 14:21 |
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It’s Folding Season again and I have found a source of electrons so that my 1080 ti can churn 24/7 and not jack up my electric bill. I will begin pushing Team Oppositelock soon. I still have some team stickers left over. Easter will make one year. We are holding at 240.
Stef Schrader
> chaozbandit
10/28/2020 at 16:03 |
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Nice!